4 CMC Crystal
$200.00 – $5,500.00
Product Information and Description
Legality of 4 CMC Crystal
Clephedrone is an Anlage I controlled drug in Germany.
Sweden’s public health agency suggested classifying 4 CMC Crystal (4-Chloromethcathinone) as illegal narcotic on June 1, 2015. As of October 2015 4 CMC Crystal is a controlled substance in China.
4 CMC Crystal is considered a Schedule 1 substance in Virginia. In December 2019, the UNODC announced scheduling recommendations placing 4 CMC Crystal into Schedule II.
The 4-chloromethcathinone (4-CMC) is a synthetic derivative of cathinone and belongs to new psychoactive substances and Neither data on the effects of 4-CMC on the human body, nor on nontoxic, toxic and lethal concentrations in biological materials have been published in the literature.
This paper describes the results of an analysis of the blood concentrations of 4-CMC determined in 15 forensic cases related to nonfatal intoxication including driving under the influence, and fatalities including overdoses, suicide and traffic accidents.
A new method for the quantification of 4-CMC using gas chromatography–mass spectrometry (GC–MS) was developed. The symptoms of 4-CMC use were also studied based on an analysis of the documents prepared during the collection of samples or at autopsies.
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The limits of detection and quantification of the method for blood samples were 0.3 and 1 ng/mL, respectively. The calibration curve was linear in the studied concentration range (1–500 ng/mL) with the correlation coefficient at 0.9979.
The extraction recoveries varied in the range of 94.3–98.8%. The accuracy and precision were acceptable. The determined concentrations in nonfatal cases ranged from 1.3 to 75.3 ng/mL, and in fatalities from 56.2 to 1870 ng/mL.
Our study can assist in the recognition of the possible effects caused by 4-CMC and can be helpful during the preparation of forensic toxicological opinions for courts of law. The validation parameters indicate the sensitivity and accuracy of the method.
This is the first work presenting a validated method for the determination of 4-CMC and in blood samples by GC–MS.
Standards and chemicals
A certified standard solution of 4-CMC monohydrochloride in methanol at a concentration of 1 mg/mL (as a free base) was manufactured by Cayman Chemicals (Ann Arbor, MI, USA); a methanolic solution of racemic-methamphetamine-d5 (rac-mAMP-d5) at a concentration of 0.1 mg/mL was manufactured by LGC Standards (London, UK).
Both solutions were delivered by a subdivision of LGC Standards (Dziekanów Leśny, Poland).
Acetonitrile (HPLC grade purity) was purchased from Merck Millipore (Warsaw, Poland); 1-chlorobutane (HPLC grade) and pentafluoropropionic anhydride (PFPA)
(99% purity) from Sigma-Aldrich (Warsaw, Poland); hydrochloric acid (HCl) at a concentration of 35–38%, potassium carbonate (K2CO3) and sodium chloride (NaCl) powder (all analytical grade) from POCH (Gliwice, Poland).
Pure water was produced by a Millipore Synergy 185 ultra-pure water system (Millipore, Warsaw, Poland).
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